49ers Vs Seahawks Betting Odds: Best Bets for TNF Week 6

The San Francisco 49ers are 3.5-point road favorites against the Seattle Seahawks on Thursday Night Football.
There are -130 odds favoring the 49ers’ 25.5-point total to go over in Week 7.
Brandon Aiyuk is the best bet to score a touchdown in the game at +163 odds, with George Kittle at +170 odds a close second.

Seattle – The Week 6 edition of Thursday Night Football features a key divisional battle between the San Francisco 49ers (-3.5) and the Seattle Seahawks. San Francisco has -180 legal sports betting odds to win outright and retake first place in the NFC West.

San Francisco 49ers Vs Seattle Seahawks Betting Odds

Team	Spread	Moneyline	Total
San Francisco 49ers	-3.5 (-105)	-180	O49.0 (-110)
Seattle Seahawks	+3.5 (-115)	+155	U49.0 (-110)

Both teams lost outright in Week 5 as favorites of seven points or more. Seattle is a 3.5-point legal Washington sports betting underdog, having lost five consecutive games against the 49ers since 2022, losing by an average of 15.2 points per game.

Best Bet: San Francisco Over 25.5 Points

The best bet of the game is the over (-130) on San Francisco’s team points total set at 25.5 points.
That’s right around their season average of 25.2 points per game.
The 49ers have cleared this projection in four of their last five games against Seattle.

San Francisco 49ers Points Prop

Over 25.5 Points -130
Under 25.5 Points +100

Touchdown Scorer Best Bets: Aiyuk (+163), Kittle (+170)

Brock Purdy could have similar success as Goff in Week 6, so there’s good value on betting his top pass catchers to find the end zone against Seattle. Wide receiver Brandon Aiyuk (+163) and tight end George Kittle (+170) are the best bets at legal NFL betting sites to score on Thursday night.

TNF Anytime Touchdown Scorer Odds

Jordan Mason -176
Kenneth Walker -125
Deebo Samuel +125
DK Metcalf +140
Brandon Aiyuk +163
George Kittle +170
Jaxon Smith-Njigba +200
Tyler Lockett +250
Jauan Jennings +260
Zach Charbonnet +300

Seattle’s Defense Vulnerable To Top Receivers

The Seahawks surrendered touchdowns to the top two receivers for the New York Giants (Darius Slayton, Wan’Dale Robinson) last week and gave up touchdowns to Amon-Ra St. Brown and Jameson Williams the week before. Aiyuk had eight catches on 12 targets in Week 5, but still hasn’t found the end zone yet this season.

George Kittle Aiming for Fourth-Consecutive Touchdown

While Aiyuk is due for a touchdown against Seattle’s vulnerable pass defense, George Kittle aims for a fourth-consecutive game with a touchdown. Kittle has +170 legal California sports betting odds to keep his streak alive after tying Aiyuk with a season-high 12 targets last week.

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Zachary Kelley

Zach graduated from Florida State University with a degree in Writing, Editing, and Media. Zach is interested in the legalization aspect of sports betting and enjoys participating in DFS. He has a passion for sports writing and most enjoys writing about football and baseball both professional and collegiate.