Best Bet for Big Monday: Take Duke ATS vs Louisville

• The Duke Blue Devils are an 18.5-point favorite at home over a struggling Louisville Cardinals team.
• With Louisville’s struggles and Duke’s strong play against weaker teams, taking Duke to cover the 18.5-point spread with -110 is the best bet for Big Monday.

DURHAM, N.C. – The Louisville Cardinals are 18.5-point underdogs tonight when they travel to Cameron Indoor Stadium to take on the Duke Blue Devils.

Louisville has played arguably the best basketball of their season over their past three games, with two losses to ranked teams by a combined 11 points and a win by ten at the Clemson Tigers.

Despite that relative success, betting on the Blue Devils to cover the spread against a 4-23 Cardinals team is the best bet for tonight’s nationally televised game.

Duke vs Louisville Odds

Betting on Duke to Cover

Betting on Duke to cover the spread versus Louisville is the best at college basketball betting sites tonight for a multitude of reasons.

According to the widely used KenPom rankings, Duke is ranked 34 while Louisville is 278 nationally.

To put Louisville’s rankings into perspective, they are the worst team that Duke has played this season, falling behind Non-Power Five or Group of Five schools like:

• Bellarmine (272)
• South Carolina Upstate (266)
• Maryland Eastern Shore (250)
• Delaware (231)
• Jacksonville (229)

Duke beat all those teams by an average of 30.2 points per game, winning four of the five games by 27 or more points.

This game being in Durham also helps the case for betting on the Blue Devils, as location has been an important factor for both teams this season:

• Duke at Home: 13-0
• Louisville on Road: 0-8

Louisville has faced five teams ranked as high or higher than Duke this season (played Miami twice), going 0-6 in the process.

Betting on that trend to continue in a loss by at least 19 points at legal sports betting sites is the best bet for Big Monday on ESPN.