Best March Madness Bracket Busters for Your Bet Slip: 13 Seeds vs 4 Seeds

• A 13 seed upsetting a 4 seed has happened eight times in the last eight March Madness tournaments.
• Yale (+260), High Point (+290), Akron (+700), and Grand Canyon (+430) are this year’s 13 seeds and all have a shot at pulling the signature 13 vs 4 upset.
• Our best bets to continue this trend are Yale vs Texas A&M and High Point vs Purdue.

DENVER – There has been at least one No. 4 team to lose in the first round in 17 of the last 23 March Madness tournaments, including eight upsets over the last eight tournaments. Each of this year’s four No. 13 seeds has what it takes to cash in some major legal sports betting profit with an outright win.

13 vs 4 Seed Matchups

• 13 Yale (+260) Vs 4 Texas A&M
• 13 High Point (+290) Vs 4 Purdue
• 13 Akron (+700) Vs 4 Arizona
• 13 Grand Canyon (+430) Vs 4 Maryland

Last year Yale pulled off the 13 vs 4 upset against Auburn, making it back-to-back years with the signature upset after Furman took down Virginia in 2023. The history of 13 vs 4 is strong and presents plenty of value for the 2025 March Madness tournament.

Yale, High Point Best Bets To Pull Upsets In March

The Yale Bulldogs are once again a 13 seed and have the shortest odds (+260) to pull the 13 vs 4 upset against the Texas A&M Aggies. Texas A&M opened as a 7.5-point favorite at legal Texas sports betting apps apps but the line has already moved down to an even seven points.

Texas A&M’s late season struggles (2-5 in last seven games) make them the biggest candidate for a first-round exit against a dangerous Yale squad. The Bulldogs won the Ivy League tournament and 16 of their last 17 games, so back their +260 longshot odds in this one.

Our other best bet to pull off the 13 vs 4 seed upset is the High Point Panthers with +290 odds at legal college basketball betting sites against the Purdue Boilermakers. High Point went 29-5 en route to a Big South Championship, winning their last 14 games.

Purdue is notorious for losing early in March Madness, as they lost as a 4 seed to North Texas back in 2021 and are one of two teams in history to lose to a 16 seed as a 1 seed. The Boilermakers have a 3-4 record as a No. 4 seed in March Madness and are vulnerable to another upset in this year’s tournament.

The other two 13 seeds (Akron, Grand Canyon) also have what it takes to pull off the upset, but they’re better bets on the spread instead of outright winners. Akron is a 14.0-point underdog to Arizona while Grand Canyon has -115 odds to cover the 10.5-point spread against Maryland.

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