Bet Cardinals vs. 49ers Week 5: Best Odds and Player Props

• Bet the Under 49.5 (-110): An inflated total, Cardinals-49ers games typically have an over-under around 42 points.
• Take Deebo Samuel Rushing Under 14.5 Yards (-115): Deebo’s rushing production has dipped, averaging just 13.1 yards per game since 2023.
• Kyler Murray Rushing Over 30.5 Yards (-115): Kyler has surpassed this total in five of six matchups against the 49ers.

SAN FRANCISCO – The Arizona Cardinals travel to California as touchdown underdogs in a divisional battle against the San Francisco 49ers on Sunday.

Only covering once in their last seven road games against the NFC West, the Cardinals’ matchup trends don’t have much support because of Kyler Murray.

Murray hasn’t played in the last five divisional road games, as his last one was in October 2022 (a 19-9 loss against Seattle). Even further, his one before that was against the Rams in 2021 (Won 37-20).

Without much experience since his rookie and sophomore seasons, a lot has changed for both the Cardinals and 49ers. One thing that hasn’t is the spread, which favors San Fran by 7.5 points.

Arizona Cardinals Vs San Francisco 49ers Betting Odds

Team	Spread	Moneyline	Total
Arizona Cardinals	+7.5 (-115)	+285	O49.5 (-110)
San Francisco 49ers	-7.5 (-105)	-370	U49.5 (-110)

Though many look at spreads first on legal NFL betting sites, the over-under flags more talking points.

This is the highest over-under that the Cardinals-49ers matchup has ever seen, with past meetings sitting closer to 42 points. But, as the over has hit in five of the last six, Kyler’s appearance doesn’t seem to matter.

Also, the last five times the spread was six or more points (with or without Kyler), the over hit every time.

But another touchdown added to the total might be too high and legal sports betting sites may be inflating the player props as well.

Best Deebo Samuel Player Prop Bet

The 49ers always do a great job of getting Deebo Samuel involved in the ground game. In the last 39 games, Deebo had one or more carries in all of them while scoring 16 rushing TDs.

But he’s trending downward, even with Christian McCaffrey on the IR.

While he has broken this marker in 20 of his last 39 games, most came in 2021-2022 when he averaged 6.5 carries per game. Since the 49ers 2022 bye week, Deebo has averaged 2.8 carries per game for 14.4 yards (8 TDs).

Even further, Deebo is averaging 13.1 rush yards per game on 2.6 carries since their bye week in 2023.

How Many Yards Will Deebo Samuel Rush For vs The Cardinals?

• Over 14.5 -115
• Under 14.5 -115

With an over-under at 14.5 yards, this Deebo prop bet should have bettors focused on the under.

In his last four games vs Arizona, he’s had 8 carries for 58 yards and a TD. A strong focus goes on the last three though, which saw him rush for 4, 6, and 11 yards.

On top of that Jordan Mason has shown consistency with legal online sportsbooks posting a projection of 85.5 yards with heavy shading (-130 odds) on the over.

Kyler Murray Player Props

Set to throw for a total of 219.5 yards, Murray averages 219.66 passing yards vs the Niners, beating this projection in four of six career games. But he’s only beaten this prop total in half of his last 12 games since returning from injury.

Also, the Niners have held 12 teams under 205 passing yards since the start of last year (21 games). This includes the 49ers defense keeping five QBs under 200 yards in the last six regular season games.

But we all know nobody is betting unders at California online betting sites as everyone wants to see the over hit. With trends so tight on passing, try focusing on rushing yards.

How Many Yards Will Kyler Murray Rush For vs the 49ers?

• Over 30.5 -115
• Under 30.5 -115

Needing 31 yards to hit this over, it should be rather attainable for Kyler. Despite rushing for 1 yard on 7 attempts against the 49ers in early 2021, in the other five matchups, he’s crushed this number.

Kyler Murray vs. 49ers Rush Attempts and Yards

Game	Rush Attempts	Rush Yards
Week 9, 2019	5	34
Week 11, 2019	8	67
Week 1, 2020	13	91
Week 16, 2020	8	75
Week 5, 2021	7	1
Week 15, 2023	6	49

With at least five carries in five of the 12 games since returning last season, he’s averaging nearly seven yards a carry. And while he only had one rush yard last week, he’s hit 45+ every other game this season.

If betting overs, this is the best Kyler Murray prop bet to consider.

News tags: Arizona Cardinals | California | Christian McCaffrey | Deebo Samuel | Jordan Mason | Kyler Murray | NFC West | NFL | Rams | San Francisco 49ers | Seattle