Betting On March Madness East Region Odds

• Purdue has +300 odds to win March Madness.
• Duke has +195 odds to reach the Elite 8.
• Tennessee is a 10.5-point favorite of UL Lafayette.

ORLANDO, Fla. – The official 2023 March Madness bracket is set and the East Region of the bracket has six teams in the top 20 of the March Madness odds board to win the tournament.

March Madness betting lines on legal online sportsbooks for the East Region are all led by the Purdue Boilermakers who have the shortest odds on all region futures.

East Region National Championship Odds

• Purdue +1200
• Marquette +2000
• Tennessee +2200
• Duke +3000
• Kentucky +3500
• Kansas State +4500
• Michigan State +6000
• Providence +10000
• USC +15000
• Oral Roberts +30000

East Region Odds To Make Elite 8

• Purdue +135
• Duke +195
• Marquette +195
• Tennessee +210
• Kansas State +375
• Kentucky +450

East Region Odds To Make Sweet 16

• Purdue -350
• Marquette -150
• Tennessee -140
• Kansas State +145
• Kentucky +155
• Duke +180

Since the 2014-15 season, Purdue has made the tournament seven times and has only gone beyond the Sweet 16 once. They’ve also been eliminated within the first two rounds three times. They went into the season with +6600 odds to win the National Championship.

The last time they had +6000 or more preseason odds, they went to the Elite 8.

This is Duke’s second March Madness appearance in the last four seasons, however, they have the most tournament experience on any team in their region. Since their National Championship win in 2009-10, they’ve made it to the Elite 8 or better five times.

The Marquette Golden Eagles are the #2 seed in the tournament; however, their tournament resume is not impressive at all. They’ve made the tournament just three times in the last three seasons and were sent home in the first round of all three.

Marquette last had +2000 preseason March Madness odds in 2011-12 and went to the Sweet 16.

Tennessee is another team that has plenty of tournament experience in recent seasons making it in four of the last five seasons but has only made it out of the second round three times. Not to mention, they’ve been a 5-seed or higher in all of those appearances.

Kentucky last won the NCAA Tournament in 2011-2012 and has made the tournament in seven of the 11 years since then. In four of those years, they’ve been able to muscle in four Elite 8 appearances or better.

Kentucky last had more than +4000 March Madness odds heading into the tournament in 2011-12 and went to the National Championship game.

Round Of 64 East Region Games To Watch

#5 Duke Vs. #12 Oral Roberts

• Spread: Duke -6.5
• Total: 146 Points

Duke has been hot against the spread in their last eight games going 6-2 ATS during that stretch. They’ve also won by 6+ points in six of those eight games as well.

It’s hard not to look at Oral Roberts pulling the upset here with a 17-game win streak going into the game. Also, in 31 of the last 36 years, there has been at least one #12-seeded team to pull off the upset.

#4 Michigan State Vs. #10 USC

• Spread: Michigan State -2
• Total: 137.5 Points

While many would typically expect closer games between two closer-seeded teams, this has been a chalked matchup with #10 seeds winning at just a 39.6% rate since 1985. Since 2010, they are 18-26.

Both USC and Michigan State are going into the game with similar outcomes on the season and in their recent games. USC is 17-15 ATS while MSU went 15-16. Both have failed to cover the spread in three of their last four games and have hit the over in points in at least three of their last five games as well.

#8 Memphis Vs. #9 Florida Atlantic

• Spread: Memphis -2
• Total: 153.5 Points

This matchup is as close to a 50/50 split that a bettor could get. #9 seeds hold a 76-72 all-time record against #8 seeds and have gone at least 3-1 in the first round in three of the last five seasons.

The 50/50 split is expected in this matchup between Memphis and FAU with both teams going into the game hot as ever. Memphis is 6-1 in their last seven games and 4-3 ATS. That stretch includes a win over the #1 ranked Houston Cougars.

FAU is 10-1 in their last 11 games and is one of the best teams in the country against the spread at 21-10-1.