March Madness Futures Odds Heading Into Thursday's Sweet Sixteen Games

With just 16 teams remaining in March Madness, the Duke Blue Devils are favored to win the National Championship at +220 odds.
The best value on the board is the Auburn Tigers at +500 odds.
The Florida Gators have a great path to the Championship game but have the second-shortest odds (+375) to be crowned champion.

SAN ANTONIO – Only 16 teams are left in the 2025 March Madness tournament and futures odds continue to shift towards the top seeds. Duke leads the pack with +220 legal sports betting odds to win the National Championship.

College Basketball Futures: National Championship Odds

Duke (#1) +220
Florida (#1) +375
Auburn (#1) +500
Houston (#1) +500
Alabama (#2) +1600
Tennessee (#2) +1600
Michigan State (#2) +2200
Texas Tech (#3) +2200
Maryland (#4) +3000
Arizona (#4) +3500
Kentucky (#3) +5000
Mississippi (#6) +5000
Michigan (#5) +6500
BYU (#6) +7000
Purdue (#4) +7000
Arkansas (#10) +7500

The top seeds: Duke (+220), Florida (+375), Auburn (+500), Houston (+500), have unsurprisingly short odds before a massive drop with the No. 2 seeds. Alabama and Tennessee are next up with +1600 odds each at legal college basketball betting sites to win it all.

Best CBB Futures Value: Auburn Tigers +500

Auburn is a 7.5-point favorite against Michigan in the Sweet Sixteen and then will play the winner of Michigan State and Ole Miss in the Elite Eight. The Tigers already beat Ole Miss twice this year and should be legal Alabama sports betting favorites against the Spartans as Auburn performed better against common opponents like Memphis and Ohio State.

The only downside to Auburn’s +500 odds is that they would need to beat a dangerous Florida Gators squad in the Final Four. The Gators have +375 odds at FL sportsbook apps to win the National Championship and have a great path to do it.

Best Path To The Championship: Florida +375

The Gators are 6.5-point favorites against a great Maryland team, but the Terps needed a buzzer beater to get past No. 12 seed Colorado State. Florida would then play the winner of Texas Tech/Arkansas where they’d be favored again.

The Red Raiders (-5.5) expect to defeat Arkansas and face Florida, but they’ve shown that they can be caught off guard and lose bad games like their losses to Saint Joseph’s, UCF, and TCU earlier this season. If Florida advances to the Final Four, betting odds say they’re most likely to face Auburn, who they beat by nine points on the road this season.

The main obstacle for both Florida (+375) and Auburn (+500) cashing their natty futures odds is Duke on the other side of the bracket. But if anyone can takedown the favored Blue Devils, it’s these two SEC powerhouses.

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Zachary Kelley

Zach graduated from Florida State University with a degree in Writing, Editing, and Media. Zach is interested in the legalization aspect of sports betting and enjoys participating in DFS. He has a passion for sports writing and most enjoys writing about football and baseball both professional and collegiate.