Aaron Rodgers - Christian McCaffrey

  • The San Francisco 49ers are 4.0-point favorites against the New York Jets.
  • Monday Night Football odds favor the 43.0-point total to go under at -115 odds.
  • Christian McCaffrey has -200 odds to score a touchdown at any time and +300 odds to score the first touchdown of the game.

SANTA CLARA, Calif. – Week 1 of the 2024-2025 NFL season comes to a close with the San Francisco 49ers as 4.0-point favorites against the New York Jets. The defending NFC Champions have -210 legal sports betting odds, while the Jets are +175 to win outright on the road.

New York Jets Vs San Francisco 49ers Betting Odds

Team Spread Moneyline Total
New York Jets +4.0 (-110) +175 O43.0 (-115)
San Francisco 49ers -4.0 (-110) -210 U43.0 (-105)

The Jets are a solid underdog pick for Monday Night Football to cover the 4.5-point spread behind Aaron Rodgers. Kyle Shanahan is just 2-5 against the spread in Week 1, while the loser of the Super Bowl (San Francisco here) is only 5-19 against the spread in Week 1 of the following season.

San Francisco also has to handle the snap counts of top talents like Trent Williams and Brandon Aiyuk, who both missed nearly the entirety of training camp and the preseason while resolving contract issues. Although he’s insisted on playing, star running back Christian McCaffrey is questionable with a calf/Achilles injury but is favored to score a touchdown at -200 odds.

MNF Anytime Touchdown Scorer Odds Favor McCaffrey

The 2023 touchdown co-leader Christian McCaffrey leads the anytime touchdown scorer board at legal NFL betting sites with -200 odds. Breece Hall of the New York Jets is next in line with +110 odds to score at any time on Monday night.

Anytime Touchdown Scorer Odds

  • Christian McCaffrey: -200
  • Breece Hall: +110
  • Deebo Samuel: +160
  • Garrett Wilson: +160
  • Brandon Aiyuk: +175
  • George Kittle: +185
  • Mike Williams: +225
  • Tyler Conklin: +330
  • Jauan Jennings: +375
  • Jordan Mason: +450

McCaffrey has five touchdowns in his last three games dating back to last season, including two games with two touchdowns. The 2023 Offensive Player of the Year has +185 legal California sports betting odds to score two or more touchdowns against the Jets.

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