- Friday’s March Madness Sweet Sixteen picks begin with Ole Miss +3.5 at +100 odds against Michigan State.
- Bovada offers -115 odds for Tennessee to cover the 4.0-point spread against Kentucky and -110 odds for Auburn to cover -9 against Michigan.
- Take the 132.0-point total between Purdue and Houston to go under at -110 odds.
ATLANTA – We’ve gone through the markets at Bovada Sportsbook and found our best bet in each of the four Sweet Sixteen games for Friday. Take the +100 legal sports betting odds for Ole Miss to cover the 3.5-point spread against Michigan State.
- Ole Miss +3.5 (+100) Vs Michigan State
- Tennessee -4 (-115) Vs Kentucky
- Auburn -9 (-110) Vs Michigan
- Purdue Vs Houston Under 132.0 (-110)
The x-factor in this one is Ole Miss coach Chris Beard, who is one of the few coaches in this tournament that’s bested legend Tom Izzo. Beard beat Izzo in the Final Four back in 2019 with Texas Tech and is 12-6 against the spread in his 18 career NCAA tournament games, including an 8-1 ATS record when having three or more days to prepare.
Most teams have beaten Ole Miss with three-point shots this season, but the Spartans struggle here making just 31% of their three-point attempts (323rd of 364 teams). Michigan State’s best shooter Jase Richardson shoots 40.6% from three, but he just went 0-5 from that range against New Mexico.
Next up is the Tennessee Volunteers with -115 odds at legal college basketball betting sites to cover the 4.0-point spread against Kentucky. The Wildcats beat Tennessee twice this season, but its hard to beat a team three times, especially when that third meeting is in the NCAA tournament.
Kentucky lost three of their last five games as an underdog, while Tennessee won five of their last six games by an average of 9.6 points per game. Take the Volunteers to cover the 4.0-point spread in this one.
Other 2 Best Bets For Friday Sweet Sixteen Games
Auburn has -110 legal Alabama sports betting odds to cover the 9.0-point spread against Michigan. After sleepwalking through their first-round win against Alabama State, the Tigers impressed with a 12-point win over Creighton in the Round of 32.
Auburn has the defensive size and ability to counter Michigan’s seven-footers, while also possessing the perimeter defense to stop Tre Donaldson and Roddy Gayle Jr. Bruce Pearl and the Tigers are 5-1 ATS (6-0 SU) against the Big Ten since 2020, beating teams by an average of 11.6 points per game.
The best bet to close the night is the 132.0-point total between Purdue and Houston to go under at -110 odds. Purdue totals went under in both tournament games so far and Houston has the best defense in the country, allowing just 58.4 points per game this season.
Parlaying all these picks at Bovada Sportsbook comes out to a +1263 parlay. A $1,000 wager at Bovada would payout $13,630 with a win.
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News tags: Alabama | Auburn Tigers | basketball | College Basketball | Houston Cougars | Kentucky Wildcats | March Madness | Michigan | Michigan State Spartans | Michigan Wolverines | Ole Miss Rebels | Purdue Boilermakers | Tennessee Volunteers | Texas

Zach graduated from Florida State University with a degree in Writing, Editing, and Media. Zach is interested in the legalization aspect of sports betting and enjoys participating in DFS. He has a passion for sports writing and most enjoys writing about football and baseball both professional and collegiate.